Ferrier Cyrille H, Aronica Eleanora, Leijten Frans S S, Spliet Wim G M, van Huffelen Alexander C, van Rijen Peter C, Binnie Colin D
Department of Clinical Neurophysiology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
Epilepsia. 2006 Sep;47(9):1477-86. doi: 10.1111/j.1528-1167.2006.00619.x.
To determine whether highly epileptiform electrocorticographical discharge patterns occur in patients with glioneuronal tumors (GNTs) and focal cortical dysplasia (FCD) and whether specific histopathological features are related to such patterns.
The series consists of operated patients with pharmacoresistant epilepsy because of FCD or GNT between 1992 and 2003. Electrocorticography was reviewed for presence of continuous spiking, bursts, recruiting discharges, or sporadic spikes. Surgical specimens were reviewed for the presence of balloon cells, (coexisting) cortical dysplasia, and relative frequencies of neurons, glia, and microglia.
Continuous spiking was seen in 55% versus 12% of patients with FCD and GNT, respectively (p = 0.005). Bursts and recruiting discharges were seen in a similar proportion of patients with FCD or GNT. Ninety-one percent of patients with continuous spiking showed (coexisting) cortical dysplasia in contrast to 42% of patients without this pattern (p = 0.004). The presence of balloon cells and glia or microglia content were not associated with discharge patterns.
Continuous spiking, bursts, and recruiting discharges occur in patients with FCD and GNT. Continuous spiking was seen significantly more often in patients with FCD. When continuous spiking is found with GNT, it is likely to be associated with dysplastic regions with a high neuronal density.
确定在神经胶质神经元肿瘤（GNTs）和局灶性皮质发育不良（FCD）患者中是否会出现高度癫痫样的皮质电图放电模式，以及特定的组织病理学特征是否与这种模式相关。
该系列研究对象为1992年至2003年间因FCD或GNT而药物难治性癫痫的手术患者。回顾皮质电图，观察是否存在持续棘波、阵发、募集性放电或散在棘波。对手术标本进行检查，观察是否存在气球样细胞、（并存的）皮质发育不良，以及神经元、胶质细胞和小胶质细胞的相对频率。
FCD患者和GNT患者中分别有55%和12%出现持续棘波（p = 0.005）。FCD或GNT患者中出现阵发和募集性放电的比例相似。有持续棘波的患者中有91%显示（并存）皮质发育不良，而无此模式的患者中这一比例为42%（p = 0.004）。气球样细胞的存在以及胶质细胞或小胶质细胞含量与放电模式无关。
FCD和GNT患者中会出现持续棘波、阵发和募集性放电。FCD患者中持续棘波的出现明显更常见。当GNT患者出现持续棘波时，可能与神经元密度高的发育异常区域有关。
