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2%多佐胺对视网膜血流的影响：一项针对已接受0.5%噻吗洛尔治疗的青少年原发性开角型青光眼患者的研究。

Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol.

作者信息

Costagliola Ciro, Campa Claudio, Parmeggiani Francesco, Incorvaia Carlo, Perri Paolo, D'Angelo Sergio, Lamberti Giuseppe, Sebastiani Adolfo

机构信息

Department of Ophthalmology, University of Ferrara, Ferrara, Italy.

出版信息

Br J Clin Pharmacol. 2007 Mar;63(3):376-9. doi: 10.1111/j.1365-2125.2006.02768.x. Epub 2006 Sep 19.

DOI:10.1111/j.1365-2125.2006.02768.x
PMID:16981897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2000725/
Abstract

AIM

To investigate whether dorzolamide modifies peripapillary retinal haemodynamics in juvenile primary open-angle glaucoma (JPOAG) patients treated with timolol.

METHODS

In 40 JPOAG subjects, before and after dorzolamide coadministration with timolol, the following examinations were achieved: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), heart rate (HR), visual field and retinal flowmetry.

RESULTS

Adjunctive therapy with dorzolamide induced the following modifications: IOP reduction [1.75 mmHg, 95% confidence interval (CI) 1.23, 2.26; P < 0.05], OPP increase (5.09 mmHg, 95% CI 2.97, 7.20; P < 0.02) and retinal blood flow improvement (35.0 arbitrary units, 95% CI 12.20, 57.80; P < 0.03). BP, HR and visual field indices did not change.

CONCLUSIONS

Dorzolamide, in association or in fixed combination with timolol, significantly improves retinal blood flow in JPOAG patients.

摘要

目的

研究多佐胺对接受噻吗洛尔治疗的青少年原发性开角型青光眼（JPOAG）患者视乳头周围视网膜血流动力学的影响。

方法

对40例JPOAG患者，在多佐胺与噻吗洛尔联合用药前后，进行以下检查：眼压（IOP）、血压（BP）、眼灌注压（OPP）、心率（HR）、视野和视网膜血流测量。

结果

多佐胺辅助治疗引起以下变化：眼压降低[1.75 mmHg，95%置信区间（CI）1.23，2.26；P < 0.05]，眼灌注压升高（5.09 mmHg，95% CI 2.97，7.20；P < 0.02），视网膜血流改善（35.0任意单位，95% CI 12.20，57.80；P < 0.03）。血压、心率和视野指标未改变。

结论

多佐胺与噻吗洛尔联合或固定复方使用，可显著改善JPOAG患者的视网膜血流。

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Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension.多佐胺和噻吗洛尔对原发性开角型青光眼和高眼压症患者眼血流的影响。
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The age-dependent decrease in the myogenic response of retinal arterioles as studied with the Retinal Vessel Analyzer.使用视网膜血管分析仪研究视网膜小动脉肌源性反应的年龄依赖性降低。
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