紫色色杆菌自诱导剂N-十二烷酰-DL-高丝氨酸内酯对小鼠和人类细胞的激活作用
Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer.
作者信息
Gomi Kazunori, Kikuchi Toshiaki, Tokue Yutaka, Fujimura Shigeru, Uehara Akiko, Takada Haruhiko, Watanabe Akira, Nukiwa Toshihiro
机构信息
Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-machi, Aoba-Ku, Sendai 980-8575, Japan.
出版信息
Infect Immun. 2006 Dec;74(12):7029-31. doi: 10.1128/IAI.00038-06. Epub 2006 Sep 18.
Abstract
Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C(12)-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-kappaB signaling pathway besides their quorum-sensing role, like 3-oxo-C(12)-HSL from Pseudomonas aeruginosa.
摘要
紫色色杆菌产生自诱导物，包括高丝氨酸内酯（HSLs），用于基因调控。在我们评估的源自紫色色杆菌的七种HSLs中，只有C(12)-HSL除了具有群体感应作用外，还通过激活NF-κB信号通路刺激哺乳动物单核细胞系中炎性细胞因子的产生，就像铜绿假单胞菌的3-氧代-C(12)-HSL一样。
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