Sulfites and skin pathology in children.

We report the case of 8 children (whose ages ranged between 2 and 7) who consulted us because of urticaria, accompanied by angioedema in 5 of the cases. An additives study was performed based on a habitual program. Sodium bisulfite hypersensitivity was detected with oral provocation test with doses of 5 and 25 mgs. The tests were positive within the first hour of observation in 2 cases, in the rest the reaction appeared later after the administration of the second dose; the reaction in 2 of the cases were semi-delayed. No respiratory symptomatology was detected in these patients.