Mega S, Miyamoto M, Li L, Kadoya M, Takahashi R, Hase R, Kaneko H, Shichinohe T, Kawarada Y, Itoh T, Morikawa T, Kondo S
Surgical Oncology, Cancer Medicine, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Dis Esophagus. 2006;19(5):355-9. doi: 10.1111/j.1442-2050.2006.00604.x.
Despite advances in the treatment of esophageal carcinoma, the prognosis for this disease remains poor. Therefore, it is important to obtain a better understanding of the molecular basis of esophageal carcinogenesis. The purpose of this study was to clarify the roles of survivin in esophageal squamous cell carcinoma (ESCC). One hundred 22 ESCC surgical specimens resected from 1989 to 1999 were examined. Survivin expression was assessed by immunohistochemistry. Tumor cells were considered survivin-positive if the immunoreactivity was confined to the nucleus, and a scoring method was applied. Survivin-positive immunostaining was detected in 68 patients (56%). There was a significant association between survivin expression and pN (P = 0.0472). Moreover, the overall survival rate was worse in patients with survivin-positive tumors than in patients with survivin-negative tumors (P = 0.0189). The overexpression of survivin was associated with the overall survival rate and poor prognosis in patients with ESCC. Survivin may be targeted during cancer therapy because of its selective expression in malignant tissue.
尽管食管癌治疗取得了进展，但该疾病的预后仍然很差。因此，更好地了解食管癌发生的分子基础很重要。本研究的目的是阐明生存素在食管鳞状细胞癌（ESCC）中的作用。对1989年至1999年切除的122例ESCC手术标本进行了检查。通过免疫组织化学评估生存素表达。如果免疫反应局限于细胞核，则肿瘤细胞被认为是生存素阳性，并应用评分方法。68例患者（56%）检测到生存素阳性免疫染色。生存素表达与pN之间存在显著关联（P = 0.0472）。此外，生存素阳性肿瘤患者的总生存率低于生存素阴性肿瘤患者（P = 0.0189）。生存素的过表达与ESCC患者的总生存率和不良预后相关。由于生存素在恶性组织中的选择性表达，它可能成为癌症治疗的靶点。
