Liver Centre, The London Clinic, London, United Kingdom.
J Med Virol. 2014 Mar;86(3):484-6. doi: 10.1002/jmv.23766. Epub 2013 Sep 30.
Described is the case of a 21-year-old male patient who presented with a severe Epstein-Barr virus (EBV) hepatitis. The initial diagnosis was challenging, as the patient did not have the typical features of the mononucleosis syndrome and despite the severity of the hepatitis, the initial serology was negative. In addition the liver biopsy did not show the mononuclear cell infiltration typically seen in EBV hepatitis. Later, measurements of EBV DNA showed high titers and the patient received a course of oral valganciclovir, following which he made a rapid clinical and serological response. This case describes an unusual presentation of EBV hepatitis, and adds to the body of evidence supporting its treatment with valganciclovir.
本文描述了一例 21 岁男性患者，其患有严重的 EBV 肝炎。最初的诊断具有挑战性，因为患者没有单核细胞增多症综合征的典型特征，尽管肝炎严重，但最初的血清学检查为阴性。此外，肝活检未显示 EBV 肝炎中通常见到的单个核细胞浸润。后来，EBV DNA 的测量显示高滴度，患者接受了口服缬更昔洛韦治疗，之后他的临床和血清学反应迅速。本病例描述了 EBV 肝炎的一种不常见表现，并为支持用缬更昔洛韦治疗该病提供了更多证据。
