Clinical Department, First Division, National Institute for Infectious Diseases "Lazzaro Spallanzani", Via Portuense 292, 00149, Rome, Italy.
Infection. 2013 Feb;41(1):251-4. doi: 10.1007/s15010-012-0303-0. Epub 2012 Jul 27.
We describe the case of an 18-year-old immunocompetent male patient with severe hepatitis during primary Epstein-Barr virus infection, treated with oral valganciclovir. During the initial therapy with corticosteroids, the patient's clinical condition and liver function worsened, so we decided to add oral valganciclovir for its good bio-availability and previous encouraging experiences in different clinical settings, with rapid resolution of the symptoms.
我们描述了一例 18 岁免疫功能正常的男性患者，在原发性 EBV 感染期间发生严重肝炎，接受口服缬更昔洛韦治疗。在最初使用皮质类固醇激素治疗期间，患者的临床状况和肝功能恶化，因此我们决定加用口服缬更昔洛韦，因为其生物利用度好，并且在不同临床环境中有令人鼓舞的既往经验，症状迅速缓解。
