Boschetto P, Fabbri L M, Zocca E, Milani G, Pivirotto F, Dal Vecchio A, Plebani M, Mapp C E
J Allergy Clin Immunol. 1987 Sep;80(3 Pt 1):261-7. doi: 10.1016/0091-6749(87)90028-5.
To determine the importance of airway inflammation for late asthmatic reactions induced by toluene diisocyanate (TDI), we investigated whether prednisone prevented them [corrected] by modifying the associated airway inflammatory reaction. We measured FEV1 before and at regular intervals after exposure to TDI and performed bronchoalveolar lavage at 8 hours after TDI in two groups of subjects with previously documented late asthmatic reactions, in one group, after no treatment, and in the other group, after treatment with prednisone (50 mg/day for 4 days). After no treatment, each subject developed a late asthmatic reaction, an increase in airway responsiveness, polymorphonuclear leukocytosis, and increased albumin in bronchoalveolar lavage. By contrast, after treatment with prednisone, no subject developed a late asthmatic reaction or an increase in airway responsiveness, and the number of leukocytes and the concentration of albumin were normal in bronchoalveolar lavage. These results suggest that late asthmatic reactions induced by TDI may be caused by airway inflammation and that prednisone may block them [corrected] by inhibiting the inflammatory reaction of the airway induced by TDI in sensitized subjects.
为了确定气道炎症在甲苯二异氰酸酯（TDI）诱发的迟发性哮喘反应中的重要性，我们研究了泼尼松是否通过改变相关的气道炎症反应来预防这些反应[已修正]。我们在两组先前有迟发性哮喘反应记录的受试者中，测量了暴露于TDI之前和之后定期的第一秒用力呼气量（FEV1），并在TDI暴露8小时后进行了支气管肺泡灌洗，一组未治疗，另一组用泼尼松治疗（50毫克/天，共4天）。未治疗时，每个受试者都出现了迟发性哮喘反应、气道反应性增加、多形核白细胞增多以及支气管肺泡灌洗中白蛋白增加。相比之下，用泼尼松治疗后，没有受试者出现迟发性哮喘反应或气道反应性增加，支气管肺泡灌洗中的白细胞数量和白蛋白浓度正常。这些结果表明，TDI诱发的迟发性哮喘反应可能由气道炎症引起，并且泼尼松可能通过抑制致敏受试者中TDI诱发的气道炎症反应来阻止这些反应[已修正]。
