Bonassar L J, Vacanti C A
Department of Anesthesiology, University of Massachusetts Medical School, Worcester 01655, USA.
J Cell Biochem Suppl. 1998;30-31:297-303.
This article reviews the important developments in the field of tissue engineering over the last 10 years. Research in the area of biomaterials is examined from the perspective of providing the foundation for the development of tissue engineering. Early efforts combining cells with biocompatible materials are described and applications of this technology presented, with particular focus on uses in orthopaedics and maxillofacial surgery. The basic principles of tissue engineering and state-of-the-art technology in cell biology and materials science as used currently in the field are presented. Finally, futures challenges are outlined from the perspective of integrating technologies from medicine, biology, and engineering, in hopes of translating tissue engineering to clinical applications.
本文回顾了过去10年组织工程领域的重要进展。从为组织工程发展提供基础的角度审视了生物材料领域的研究。描述了早期将细胞与生物相容性材料相结合的努力，并介绍了该技术的应用，尤其侧重于在骨科和颌面外科的应用。阐述了组织工程的基本原理以及该领域目前所使用的细胞生物学和材料科学的前沿技术。最后，从整合医学、生物学和工程学技术的角度概述了未来的挑战，以期将组织工程转化为临床应用。
