Tang Shengzhuang, Martinez Lynda J, Sharma Ajit, Chai Minghui
Department of Chemistry, Central Michigan University, Mt. Pleasant, Michigan 48859, USA.
Org Lett. 2006 Sep 28;8(20):4421-4. doi: 10.1021/ol061449l.
A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.
一种小的药物分子L-多巴被转化为结构明确的树枝状大分子。核磁共振（NMR）、基质辅助激光解吸电离飞行时间质谱（MALDI-TOF-MS）和聚丙烯酰胺凝胶电泳（PAGE）证明了它们的单分散性质。第三代L-多巴树枝状大分子含有30个L-多巴残基，这些残基构成了其核心、分支和外围。树枝状大分子中的单个L-多巴部分通过可水解的二酯键相互连接。在相同条件下，这些多巴树枝状大分子在水溶液中的溶解度比L-多巴提高了20倍，并且在溶液中的光稳定性增强。
