da Silva Santos Soraya, Igne Ferreira Elizabeth, Giarolla Jeanine
Laboratory of Design and Synthesis of Chemotherapeutics Potentially Active in Neglected Diseases (LAPEN), Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo-USP, Avenue Professor Lineu Prestes, 580-Building 13, São Paulo SP, 05508-900, Brazil.
Molecules. 2016 May 31;21(6):686. doi: 10.3390/molecules21060686.
The main objective of this review is to describe the importance of dendrimer prodrugs in the design of new drugs, presenting numerous applications of these nanocomposites in the pharmaceutical field. Therefore, the use of dendrimer prodrugs as carrier for drug delivery, to improve pharmacokinetic properties of prototype, to promote drug sustained-release, to increase selectivity and, consequently, to decrease toxicity, are just some examples of topics that have been extensively reported in the literature, especially in the last decade. The examples discussed here give a panel of the growing interest dendrimer prodrugs have been evoking in the scientific community.
本综述的主要目的是描述树枝状大分子前药在新药设计中的重要性，介绍这些纳米复合材料在制药领域的众多应用。因此，将树枝状大分子前药用作药物递送载体、改善原型药物的药代动力学性质、促进药物缓释、提高选择性并因此降低毒性，只是文献中尤其是过去十年中广泛报道的一些主题示例。这里讨论的例子展示了树枝状大分子前药在科学界引起的越来越多的关注。
