Krupkova Alena, Cermak Jan, Walterova Zuzana, Horský Jirí
Institute of Chemical Process Fundamentals, Academy of Sciences of the Czech Republic, Rozvojová 2, 16502 Prague 6, Czech Republic.
Anal Chem. 2007 Feb 15;79(4):1639-45. doi: 10.1021/ac061783v.
A general relationship is derived for the abundance of an imperfect dendrimer with a given number of missing constitutional repeating units in the two outmost layers. The relationship is used in the interpretation of the MALDI TOF mass spectrum of the second-generation carbosilane dendrimer prepared by the iterative divergent method. The model quantitatively describes the spectrum of the dendrimer and correctly predicts the MALDI TOF mass spectrum of its first-generation precursor. Thus, the use of well-resolved MALDI TOF mass spectra for assessing the purity of low-generation dendrimers with uniform end groups is substantiated for carbosilane dendrimers and to lesser extent for dendrimers in general.
推导了一种通用关系，用于描述在最外层具有给定数量缺失结构重复单元的不完美树枝状大分子的丰度。该关系用于解释通过迭代发散法制备的第二代碳硅烷树枝状大分子的基质辅助激光解吸电离飞行时间质谱（MALDI TOF MS）。该模型定量描述了树枝状大分子的光谱，并正确预测了其第一代前体的MALDI TOF MS。因此，对于碳硅烷树枝状大分子，使用分辨率良好的MALDI TOF MS来评估具有均匀端基的低代树枝状大分子的纯度是合理的，对于一般的树枝状大分子在较小程度上也是如此。
