通过炔基硅烷催化加成到α-硅氧基醛上高非对映选择性地制备反式-1,2-二醇
Highly diastereoselective preparation of anti-1,2-diols by catalytic addition of alkynylsilanes to alpha-silyloxyaldehydes.
作者信息
Sa-ei Kanicha, Montgomery John
机构信息
Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
出版信息
Org Lett. 2006 Sep 28;8(20):4441-3. doi: 10.1021/ol061579u.
Abstract
The catalytic, diastereoselective coupling of alpha-silyloxy aldehydes and alkynylsilanes catalyzed by a nickel(0) N-heterocyclic carbene complex provides an effective entry to anti-1,2-diols. The scope of couplings and extent of diastereoselection are excellent across a range of substrates.
摘要
镍（0）氮杂环卡宾配合物催化的α-硅氧基醛与炔基硅烷的催化非对映选择性偶联反应为制备反式-1,2-二醇提供了一条有效途径。在一系列底物中，偶联反应的范围和非对映选择性程度都非常出色。
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