Natali P G, Nicotra M R, Bartolazzi A, Mottolese M, Coscia N, Bigotti A, Zardi L
Regina Elena Cancer Institute, Rome, Italy.
Int J Cancer. 1990 Oct 15;46(4):586-90. doi: 10.1002/ijc.2910460406.
The distribution of the extracellular matrix (ECM) glyco-protein tenascin (TN) has been evaluated immunohistochemically in benign and malignant lesions of the melanocytic lineage. Results of our study show that TN is detectable in a variety of benign and malignant lesions. In primary melanomas, TN displays a heterogeneous distribution, and a higher degree of expression of this glycoprotein is seen in lesions of greater dermal invasiveness. TN expression does not correlate with that of other ECM glycoproteins such as fibronectin. In vivo and in vitro experiments have also demonstrated that melanoma cells are capable of producing and releasing TN in the extracellular milieu.
已采用免疫组织化学方法评估细胞外基质（ECM）糖蛋白腱生蛋白（TN）在黑素细胞谱系良性和恶性病变中的分布。我们的研究结果表明，在多种良性和恶性病变中均可检测到TN。在原发性黑色素瘤中，TN呈异质性分布，在真皮浸润程度较高的病变中可见该糖蛋白的表达程度更高。TN的表达与其他ECM糖蛋白如纤连蛋白的表达无关。体内和体外实验还表明，黑色素瘤细胞能够在细胞外环境中产生并释放TN。
