Natali P G, Nicotra M R, Bigotti A, Botti C, Castellani P, Risso A M, Zardi L
Regina Elena Cancer Institute, Rome, Italy.
Int J Cancer. 1991 Apr 1;47(6):811-6. doi: 10.1002/ijc.2910470603.
Tenascin (TN) is a high-molecular-mass oligomeric glycoprotein of the extracellular matrix (ECM) endowed with a programmed expression in embryonic life and a neo-expression in the interstitium of some malignancies. Using monoclonal antibodies (MAbs) which identify human tenascin, we have conducted an extensive immunohistochemical analysis of TN expression in normal fetal and adult human tissues as well as in a wide variety of human tumors. Results of this study demonstrate that TN (1) is detectable in embryonic and fetal tissues at least from the 10th week of gestation; (2) is present in the interstitium of a variety of adult tissues of different embryonic origin; (3) may be neo-expressed in the stroma of benign and malignant tumors; (4) has the ability to accumulate in a highly variable manner in the ECM of tumors of the same and of different histotypes.
腱生蛋白（TN）是一种细胞外基质（ECM）中的高分子量寡聚糖蛋白，在胚胎期具有程序性表达，并在某些恶性肿瘤的间质中重新表达。利用识别人类腱生蛋白的单克隆抗体（MAb），我们对TN在正常胎儿和成人组织以及多种人类肿瘤中的表达进行了广泛的免疫组织化学分析。这项研究的结果表明，TN（1）至少从妊娠第10周起在胚胎和胎儿组织中可检测到；（2）存在于不同胚胎起源的多种成人组织的间质中；（3）可能在良性和恶性肿瘤的基质中重新表达；（4）能够以高度可变的方式在相同和不同组织学类型肿瘤的ECM中积累。
