Vervoorts Jörg, Lüscher-Firzlaff Juliane, Lüscher Bernhard
Abteilung Biochemie und Molekularbiologie, Institut für Biochemie, Klinikum, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany.
J Biol Chem. 2006 Nov 17;281(46):34725-9. doi: 10.1074/jbc.R600017200. Epub 2006 Sep 20.
The proteins of the MYC family are key regulators of cell behavior. MYC, originally identified as an oncoprotein, affects growth, proliferation, differentiation, and apoptosis of cells through its ability to regulate a significant number of genes. In addition MYC governs events associated with tumor progression, including genetic stability, migration, and angiogenesis. The pleiotropic activities attributed to MYC and their balanced control requires that the expression and function of MYC is tightly controlled. Indeed many different pathways and factors have been identified that impinge on MYC gene expression and protein function. In particular the protein is subject to different posttranslational modifications, including phosphorylation, ubiquitinylation, and acetylation. Here we discuss the latest developments regarding these modifications that control various aspects of MYC function, including its stability, the interaction with partner proteins, and the transcriptional potential.
MYC家族蛋白是细胞行为的关键调节因子。MYC最初被鉴定为一种癌蛋白，它通过调节大量基因的能力来影响细胞的生长、增殖、分化和凋亡。此外，MYC还调控与肿瘤进展相关的事件，包括遗传稳定性、迁移和血管生成。MYC的多效性活动及其平衡控制要求MYC的表达和功能受到严格调控。事实上，已经发现了许多不同的途径和因子会影响MYC基因表达和蛋白质功能。特别是该蛋白会经历不同的翻译后修饰，包括磷酸化、泛素化和乙酰化。在此，我们讨论关于这些修饰的最新进展，这些修饰控制着MYC功能的各个方面，包括其稳定性、与伴侣蛋白的相互作用以及转录潜能。
