来自绒毛鹅绒藤的强心苷及其在卡波西肉瘤细胞中的促凋亡活性。

Cardenolide glycosides from Pergularia tomentosa and their proapoptotic activity in Kaposi's sarcoma cells.

作者信息

Hamed Arafa I, Plaza Alberto, Balestrieri Maria Luisa, Mahalel Usama A, Springuel Irina V, Oleszek Wieslaw, Pizza Cosimo, Piacente Sonia

机构信息

Faculty of Science, South Valley University, Aswan 81528, Egypt.

出版信息

J Nat Prod. 2006 Sep;69(9):1319-22. doi: 10.1021/np060228l.

DOI:10.1021/np060228l

PMID:16989527

Abstract

Continuing our investigations on plants belonging to the Asclepiadaceae family, three new cardenolide glycosides, 3'-O-beta-D-glucopyranosylcalactin (1), 12-dehydroxyghalakinoside (2), and 6'-dehydroxyghalakinoside (3), along with the known ghalakinoside (4) and calactin (5), were isolated from the roots of Pergularia tomentosa. The structures of these compounds were elucidated by extensive spectroscopic methods including 1D- and 2D-NMR experiments as well as ESIMS analysis. The isolated cardenolides caused apoptotic cell death of Kaposi's sarcoma cells.

摘要

在对萝藦科植物的持续研究中，从绒毛鹅绒藤的根部分离出了三种新的强心苷类糖苷，即3'-O-β-D-吡喃葡萄糖基卡拉亭（1）、12-脱羟基加拉基诺苷（2）和6'-脱羟基加拉基诺苷（3），以及已知的加拉基诺苷（4）和卡拉亭（5）。这些化合物的结构通过广泛的光谱方法得以阐明，包括一维和二维核磁共振实验以及电喷雾离子化质谱分析。分离出的强心苷类化合物导致了卡波西肉瘤细胞的凋亡性细胞死亡。