Lester Jacobo, Otero-Siliceo Enrique
Hospital de Clínicas José de San Martín, Huixquilucan, Estado de México, Mexico.
Neurologist. 2006 Sep;12(5):240-4. doi: 10.1097/01.nrl.0000237141.29970.e3.
Idiopathic Parkinson disease (IPD) is a condition of unknown cause. Several factors are believed to contribute to its onset, and many studies have been conducted in search of the possible etiology of Parkinson disease.
Genetic factors have become relevant when trying to explain the onset of Parkinson disease. The studies are divided into 2 categories: epidemiological and studies that analyze twins from families with members suffering from Parkinson disease, thus looking for the responsible genetic mutations. In this article we address this controversial topic, reviewing some of the most significant studies trying to provide evidence which relates genetics to Parkinson disease.
We present current epidemiological studies and the most important genetic factors related to Parkinson disease, including the latest information currently available on each issue.
特发性帕金森病（IPD）是一种病因不明的疾病。人们认为有多种因素会导致其发病，并且已经开展了许多研究来探寻帕金森病可能的病因。
在试图解释帕金森病的发病机制时，遗传因素已变得至关重要。这些研究分为两类：流行病学研究以及对患有帕金森病家庭成员的双胞胎进行分析的研究，以此寻找相关的基因突变。在本文中，我们探讨这一有争议的话题，回顾一些最重要的研究，试图提供将遗传学与帕金森病相关联的证据。
我们展示了当前的流行病学研究以及与帕金森病相关的最重要的遗传因素，包括目前关于每个问题的最新信息。
