Franceschi Silvia, Herrero Rolando, Clifford Gary M, Snijders Peter J F, Arslan Annie, Anh Pham Thi Hoang, Bosch F Xavier, Ferreccio Catterina, Hieu Nguyen Trong, Lazcano-Ponce Eduardo, Matos Elena, Molano Monica, Qiao You-Lin, Rajkumar Raj, Ronco Guglielmo, de Sanjosé Silvia, Shin Hai-Rim, Sukvirach Sukhon, Thomas Jaiye O, Meijer Chris J L M, Muñoz Nubia
International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 2006 Dec 1;119(11):2677-84. doi: 10.1002/ijc.22241.
An inverse relationship between age and human papillomavirus (HPV) prevalence has been reported in many developed countries, but information on this relationship is scarce in many other parts of the world. We carried out a cross-sectional study of sexually active women from the general population of 15 areas in 4 continents. Similar standardised protocols for women's enrolment, cervical specimen collection and PCR-based assays for HPV testing were used. HPV prevalence in different age groups was compared by study area. 18,498 women aged 15-74 years were included. Age-standardised HPV prevalence varied more than 10-fold between populations, as did the shape of age-specific curves. HPV prevalence peaked below age 25 or 35, and declined with age in Italy, the Netherlands, Spain, Argentina, Korea and in Lampang, Thailand and Ho Chi Minh, Vietnam. This was not the case in Songkla, Thailand nor Hanoi, Vietnam, where HPV prevalence was low in all age groups. In Chile, Colombia and Mexico, a second peak of HPV prevalence was detected among older women. In the poorest study areas in Asia (Shanxi, China and Dindigul, India), and in Nigeria, HPV prevalence was high across all age groups. The substantial differences observed in age-specific curves of HPV prevalence between populations may have a variety of explanations. These differences, however, underline that great caution should be used in inferring the natural history of HPV from age-specific prevalences.
在许多发达国家，年龄与人乳头瘤病毒（HPV）流行率之间呈负相关关系，但世界上许多其他地区关于这种关系的信息却很少。我们对来自四大洲15个地区普通人群中的性活跃女性进行了一项横断面研究。采用了类似的标准化方案来招募女性、收集宫颈样本以及进行基于聚合酶链反应（PCR）的HPV检测分析。按研究地区比较了不同年龄组的HPV流行率。共纳入了18498名年龄在15至74岁之间的女性。年龄标准化的HPV流行率在不同人群之间相差超过10倍，年龄特异性曲线的形状也是如此。在意大利、荷兰、西班牙、阿根廷、韩国以及泰国南邦府和越南胡志明市，HPV流行率在25岁或35岁以下达到峰值，并随年龄增长而下降。在泰国宋卡府和越南河内并非如此，这两个地区所有年龄组的HPV流行率都很低。在智利、哥伦比亚和墨西哥，老年女性中检测到HPV流行率的第二个峰值。在亚洲最贫困的研究地区（中国山西和印度丁迪古尔）以及尼日利亚，所有年龄组的HPV流行率都很高。在不同人群中观察到的HPV流行率年龄特异性曲线的显著差异可能有多种解释。然而，这些差异强调，在从年龄特异性流行率推断HPV的自然史时应格外谨慎。
