Thomas J O, Herrero R, Omigbodun A A, Ojemakinde K, Ajayi I O, Fawole A, Oladepo O, Smith J S, Arslan A, Muñoz N, Snijders P J F, Meijer C J L M, Franceschi S
College of Medicine, University of Ibadan, PMB 5017, GPO, Ibadan, Nigeria.
Br J Cancer. 2004 Feb 9;90(3):638-45. doi: 10.1038/sj.bjc.6601515.
To investigate the prevalence of and the risk factors for cervical infection with human papillomavirus (HPV) in an inner-city area of Ibadan, Nigeria, we interviewed and obtained a sample of cervical cells from 932 sexually active women aged 15 years or older. A total of 32 different HPV types were identified with an HPV prevalence of 26.3% overall and 24.8% among women without cervical lesions; or age-standardised to the world standard population of 28.3 and 27.3%, respectively. High-risk HPV types predominated, most notably HPV 16, 31, 35 and 58. In all, 33.5% of infections involved more than one HPV type. Unlike most populations studied so far, HPV prevalence was high not only among young women, but also in middle and old age. Single women (odds ratio, OR=2.1; 95% confidence interval, CI=1.1-3.9) and illiterate women (OR=1.7; 95%CI=1.1-2.5) showed increased HPV positivity. Associations were also found with anti-Herpes simplex-2 antibodies (OR=1.6; 95% CI: 1.1-2.1) and with the husband's extramarital relationships (OR=1.6: 95% CI: 1.0-2.6). High prevalence of HPV in all age groups may be a distinctive feature of populations where HPV transmission continues into middle age and cervical cancer incidence is very high.
为调查尼日利亚伊巴丹市中心城区人乳头瘤病毒（HPV）宫颈感染的患病率及风险因素，我们对932名15岁及以上有性行为的女性进行了访谈并采集了宫颈细胞样本。共鉴定出32种不同的HPV类型，总体HPV患病率为26.3%，无宫颈病变的女性中患病率为24.8%；按世界标准人口年龄标准化后，分别为28.3%和27.3%。高危HPV类型占主导，最常见的是HPV 16、31、35和58型。总体而言，33.5%的感染涉及一种以上HPV类型。与迄今研究的大多数人群不同，HPV患病率不仅在年轻女性中较高，在中年和老年女性中也较高。单身女性（优势比，OR = 2.1；95%置信区间，CI = 1.1 - 3.9）和文盲女性（OR = 1.7；95%CI = 1.1 - 2.5）的HPV阳性率较高。还发现HPV感染与抗单纯疱疹病毒2型抗体（OR = 1.6；95%CI：1.1 - 2.1）以及丈夫的婚外情（OR = 1.6：95%CI：1.0 - 2.6）有关。HPV在所有年龄组中的高患病率可能是HPV传播持续至中年且宫颈癌发病率非常高的人群的一个显著特征。
