Minnear F L, Barrie P S, Malik A B
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun;50(6):1353-7. doi: 10.1152/jappl.1981.50.6.1353.
The effect of an intravenous infusion of epinephrine or norepinephrine (45 microgram.kg-1.min-1) on the transcapillary exchange of fluid and protein were studied in anesthetized sheep prepared with lung lymph fistulas. After infusion of epinephrine, pulmonary lymph flow (Qlym) and the ratio of lymph to plasma protein concentration (L/P) did not change significantly from base line despite an increase in mean pulmonary arterial pressure (Ppa) from 17.3 +/- 0.8 to 22.6 +/- 0.09 Torr, In contrast, Qlym increased (p less than 0.05) from 9.24 +/- 1.53 to 11.46 +/- 1.97 ml/h and L/P decreased (p less than 0.05) from 0.78 +/- 0.03 to 0.74 +/- 0.04 after infusion of norepinephrine; these changes were associated with an increase in Ppa from 16.5 +/- 1.5 to 21.6 +/- 1.8 Torr. Pulmonary vascular resistance (PVR) increased from 5.90 +/- 0.83 to 12.12 +/- 1.23 Torr. 1-1 min (p less than 0-.01) after epinephrine and from 6.52 +/- 0.82 to 9.26 +/- 1.74 Torr.1-1 min (p less than 0.05) after norepinephrine. Left atrial hypertension, induced in four sheep infused with norepinephrine and in five sheep infused with epinephrine by inflating a left atrial balloon, increased Qlym and decreased L/P in all animals. Thus the infusions of epinephrine or norepinephrine did not increase lung vascular permeability to proteins. Epinephrine infusion also did not increase fluid filtration despite increases in Ppa and PVR, suggesting that pulmonary microvascular pressure did not increase significantly due to greater constriction of precapillary than postcapillary vessels. However, norepinephrine infusion increased filtration, suggesting that microvascular pressure was increased due to a greater constriction of postcapillary than precapillary vessels.
在制备了肺淋巴瘘的麻醉绵羊中，研究了静脉输注肾上腺素或去甲肾上腺素（45微克·千克⁻¹·分钟⁻¹）对液体和蛋白质跨毛细血管交换的影响。输注肾上腺素后，尽管平均肺动脉压（Ppa）从17.3±0.8 Torr升高至22.6±0.09 Torr，但肺淋巴流量（Qlym）和淋巴与血浆蛋白浓度之比（L/P）与基线相比无显著变化。相比之下，输注去甲肾上腺素后，Qlym从9.24±1.53毫升/小时增加（p<0.05）至11.46±1.97毫升/小时，L/P从0.78±0.03降至0.74±0.04（p<0.05）；这些变化与Ppa从16.5±1.5 Torr升高至21.6±1.8 Torr有关。肺血管阻力（PVR）在输注肾上腺素后1 - 1分钟从5.90±0.83 Torr·升⁻¹·分钟⁻¹增加至12.12±1.23 Torr·升⁻¹·分钟⁻¹（p<0.01），在输注去甲肾上腺素后1 - 1分钟从6.52±0.82 Torr·升⁻¹·分钟⁻¹增加至9.26±1.74 Torr·升⁻¹·分钟⁻¹（p<0.05）。通过充盈左心房球囊在4只输注去甲肾上腺素的绵羊和5只输注肾上腺素的绵羊中诱发左心房高压，所有动物的Qlym均增加，L/P均降低。因此，输注肾上腺素或去甲肾上腺素并未增加肺血管对蛋白质的通透性。尽管Ppa和PVR升高，但输注肾上腺素也未增加液体滤过，这表明由于毛细血管前血管比毛细血管后血管收缩更明显，肺微血管压力并未显著升高。然而，输注去甲肾上腺素增加了滤过，表明微血管压力升高是由于毛细血管后血管比毛细血管前血管收缩更明显。
