Brébion Gildas, David Anthony S, Jones Hugh M, Ohlsen Ruth, Pilowsky Lyn S
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, London, UK.
Neuropsychologia. 2007 Mar 2;45(4):817-23. doi: 10.1016/j.neuropsychologia.2006.08.009. Epub 2006 Sep 22.
A deficit in remembering the temporal context of events (a type of source memory) has been observed in schizophrenia, and suggested to be associated with positive symptoms.
In order to investigate memory for temporal context, we administered a list discrimination task to a sample of schizophrenia patients and a sample of healthy controls. Participants were required to learn two lists of mixed high- and low-frequency words separated by 10 min, then to remember whether each word had been presented in the first or in the second list.
The number of misattributions to the wrong list was significantly higher in patients than in healthy controls. However, the group difference was eliminated when recall efficiency was covaried. The number of list misattributions was higher in patients with auditory hallucinations than in the other patients, independently of verbal recall efficiency. By contrast, affective flattening and anhedonia were associated with fewer list misattributions of the high-frequency words.
It is suggested that auditory hallucinations are associated with deficit in processing or remembering the temporal context. Conversely, certain negative symptoms are associated with reduced temporal context errors. The possible neural mechanisms involved in temporal context deficit as well as in these specific clinical symptoms are discussed.
在精神分裂症患者中观察到对事件时间背景（一种源记忆）的记忆缺陷，并提示其与阳性症状相关。
为了研究对时间背景的记忆，我们对一组精神分裂症患者样本和一组健康对照样本进行了列表辨别任务。参与者需要学习两组由10分钟间隔开的高频和低频混合单词列表，然后记住每个单词是出现在第一个列表还是第二个列表中。
患者将单词错误归因于错误列表的数量显著高于健康对照。然而，当回忆效率作为协变量时，组间差异消除。有幻听的患者列表错误归因的数量高于其他患者，且与言语回忆效率无关。相比之下，情感平淡和快感缺乏与高频单词的列表错误归因较少有关。
提示幻听与处理或记忆时间背景的缺陷有关。相反，某些阴性症状与时间背景错误减少有关。讨论了时间背景缺陷以及这些特定临床症状中可能涉及的神经机制。
