Eriksson Asa, Tengström Anders, Hodgins Sheilagh
Department of Clinical Neuroscience, Section of Alcohol and Drug Dependence Research, Karolinska Institute, Box 500, S-112 81 Stockholm, Sweden.
Addict Behav. 2007 Jun;32(6):1146-63. doi: 10.1016/j.addbeh.2006.08.003. Epub 2006 Sep 22.
Alcohol use disorders are common among persons with schizophrenia and are associated with a vast array of negative consequences: criminality, poor compliance with treatment, and reoccurrence of acute episodes of psychosis. In samples of non-mentally disordered individuals, typologies of alcohol use disorders have been shown to be useful in furthering understanding of etiology and of effective treatments. Such typologies, however, have not previously been examined in individuals with schizophrenia. The main objective of the study was to validate four uni-dimensional typologies and the multi-dimensional Type I/II-Type A/B typology in a sample of men with schizophrenic disorders and alcohol use disorders. All uni-dimensional typologies showed at least some degree of concurrent validity. The Type I/II-Type A/B typology was successfully replicated with fair concurrent validity across the domains of pre-morbid risk factors and drug use, but not for the domains of criminality, illness, or personality. The predictive validity was poor for all typologies. The results provide evidence for the heterogeneity of alcohol use disorders among men with schizophrenia.
酒精使用障碍在精神分裂症患者中很常见，并与一系列负面后果相关：犯罪、治疗依从性差以及精神病急性发作的复发。在非精神障碍个体样本中，酒精使用障碍的类型学已被证明有助于进一步理解病因和有效治疗方法。然而，此前尚未在精神分裂症患者中对这类类型学进行研究。该研究的主要目的是在患有精神分裂症和酒精使用障碍的男性样本中验证四种单维类型学以及多维的I/II - A/B类型学。所有单维类型学都显示出至少一定程度的同时效度。I/II - A/B类型学在病前危险因素和药物使用领域成功复现，具有尚可的同时效度，但在犯罪、疾病或人格领域则不然。所有类型学的预测效度都很差。研究结果为患有精神分裂症的男性中酒精使用障碍的异质性提供了证据。
