Summers Max D
Department of Entomology, Texas A&M University, College Station, Texas 77843, USA.
Adv Virus Res. 2006;68:3-73. doi: 10.1016/S0065-3527(06)68001-9.
The baculovirus expression vector system (BEVS) is widely established as a highly useful and effective eukaryotic expression system. Thousands of soluble and membrane proteins that, in general, are correctly folded, modified, sorted and assembled to produce highly authentic recombinant proteins have been cloned and expressed. This historical chronology and perspective will focus on the original, peer-reviewed discoveries that were pioneering and seminal to the development of the BEVS and that provided the basis for subsequent and more recent developments and applications.
杆状病毒表达载体系统（BEVS）作为一种非常有用且高效的真核表达系统已被广泛确立。数以千计的可溶性蛋白和膜蛋白，总体上能够正确折叠、修饰、分选和组装，从而产生高度真实的重组蛋白，这些蛋白已被克隆和表达。这一历史年表和观点将聚焦于最初经过同行评审的发现，这些发现对BEVS的发展具有开创性和重大意义，并为后续以及最近的发展和应用奠定了基础。
