Koynarski V, Stoev S, Grozeva N, Mirtcheva T, Daskalov H, Mitev J, Mantle P
Department of Parasitology, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria.
Res Vet Sci. 2007 Apr;82(2):225-31. doi: 10.1016/j.rvsc.2006.07.004. Epub 2006 Sep 25.
The progression of coccidiosis provoked by Eimeria acervulina was followed in chicks fed on OTA-contaminated as well as on OTA-free diets. More heavy progress of duodenal coccidiosis, including mortality, occurred in OTA-treated chicks as can be seen from the higher value of lesion (3.50) and oocyst (31.65) indices. A stronger decrease of serum total protein was found in OTA-treated chicks (22.80 g/l) than in chicks infected with E. acervulina(24.20 g/l), but that decrease was strongest in chicks treated with OTA and simultaneously infected with E. acervulina (19.71 g/l). The serum concentration of uric acid was significantly increased in all chicks exposed to OTA, most notably in those additionally infected with E. acervulina (1020.6 (micro mol/L), whereas the serum enzyme activity of AST was increased only in chicks infected with E. acervulina and highest in those fed OTA contaminated diet (122.2 U/L). OTA induced degenerative changes in kidneys, liver and heart as well as a depletion of lymphoid tissue in the lymphoid organs and a decrease of body weight. Coccidiosis induced only a slight growth depression and duodenal hemorrhages in addition to characteristic duodenal damages. The impairment of kidney function, histopathological changes and general growth depression were stronger when chicks infected with E. acervulina were also given OTA.
研究了在饲喂受赭曲霉毒素A（OTA）污染饲料和未受OTA污染饲料的雏鸡中，由堆型艾美耳球虫引发的球虫病进展情况。从病变指数（3.50）和卵囊指数（31.65）的较高值可以看出，OTA处理的雏鸡十二指肠球虫病进展更严重，包括死亡率更高。OTA处理的雏鸡血清总蛋白的下降幅度（22.80 g/l）比感染堆型艾美耳球虫的雏鸡（24.20 g/l）更大，但在同时接受OTA处理并感染堆型艾美耳球虫的雏鸡中下降最为明显（19.71 g/l）。所有接触OTA的雏鸡血清尿酸浓度均显著升高，在额外感染堆型艾美耳球虫的雏鸡中最为显著（1020.6微摩尔/升），而血清天冬氨酸转氨酶（AST）的酶活性仅在感染堆型艾美耳球虫的雏鸡中升高，在饲喂受OTA污染饲料的雏鸡中最高（122.2 U/L）。OTA导致肾脏、肝脏和心脏出现退行性变化，以及淋巴器官中淋巴组织的消耗和体重下降。球虫病除了导致特征性的十二指肠损伤外，仅引起轻微的生长抑制和十二指肠出血。当感染堆型艾美耳球虫的雏鸡也给予OTA时，肾功能损害、组织病理学变化和总体生长抑制更为严重。
