O'Hagan Derek T, Singh Manmohan, Ulmer Jeffrey B
Vaccines Research, Novartis Vaccines and Diagnostics, Inc., 4560 Horton Street, Mail Stop 4.3, Emeryville, CA 94608, USA.
Methods. 2006 Sep;40(1):10-9. doi: 10.1016/j.ymeth.2006.05.017.
Microparticles have been effectively used for many years as delivery systems for drugs and therapeutic proteins. Their application to the delivery of vaccines is not as extensive, but is growing. Utility has been demonstrated for the delivery of various types of vaccines (e.g., recombinant proteins, plasmid DNA, and peptides) and other vaccine components (e.g., immune potentiators). With respect to delivery of immune potentiators, synergistic effects are often observed whereby much more potent immune responses are induced with a combination than with either component alone. Hence, the prospects for broad application of microparticle-based delivery systems for vaccines are excellent.
微粒作为药物和治疗性蛋白质的递送系统已被有效应用多年。它们在疫苗递送方面的应用虽不那么广泛，但正在不断增加。已证明微粒可用于递送各种类型的疫苗（例如重组蛋白、质粒DNA和肽）以及其他疫苗成分（例如免疫增强剂）。关于免疫增强剂的递送，经常观察到协同效应，即与单独使用任何一种成分相比，组合使用时可诱导更强有力的免疫反应。因此，基于微粒的疫苗递送系统具有广阔的应用前景。
