Sohn Dae Kyung, Chang Hee Jin, Park Ji Won, Choi Dong Hyun, Han Kyung Su, Hong Chang Won, Jung Kyung Hae, Kim Dae Yong, Lim Seok-Byung, Choi Hyo Seong, Jeong Seung-Yong
Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
J Clin Pathol. 2007 Aug;60(8):912-5. doi: 10.1136/jcp.2006.043539. Epub 2006 Sep 22.
To evaluate the histopathological risk factors for lymph node metastasis in cases of pedunculated or semipedunculated submucosal invasive colorectal carcinoma (SICC).
A total of 48 patients with non-sessile SICC who underwent systematic lymph node dissection were included. Tumour size, histological grade, angiolymphatic invasion, tumour budding, dedifferentiation, objective submucosal invasion depth from the identified muscularis mucosa, relative invasion depth of the submucosal layer, and depth of stalk invasion were investigated histopathologically.
Lymph node metastasis was observed in seven cases (14.6%). Univariate analysis showed angiolymphatic invasion and tumour budding to be significantly associated with lymph node metastasis. Multivariate analysis showed that tumour budding was the only independent factor associated with lymph node metastasis in cases of non-sessile SICC.
Results indicate that tumour budding is a useful risk factor for predicting lymph node metastasis in cases of pedunculated or semipedunculated SICC.
评估有蒂或半有蒂黏膜下浸润性结直肠癌（SICC）患者发生淋巴结转移的组织病理学危险因素。
纳入48例接受系统性淋巴结清扫的非无蒂SICC患者。对肿瘤大小、组织学分级、血管淋巴管浸润、肿瘤芽生、去分化、从确定的黏膜肌层起的客观黏膜下浸润深度、黏膜下层的相对浸润深度以及蒂浸润深度进行组织病理学研究。
7例（14.6%）观察到淋巴结转移。单因素分析显示血管淋巴管浸润和肿瘤芽生与淋巴结转移显著相关。多因素分析显示，在非无蒂SICC病例中，肿瘤芽生是与淋巴结转移相关的唯一独立因素。
结果表明，肿瘤芽生是预测有蒂或半有蒂SICC病例淋巴结转移的有用危险因素。
