Ishii Hideaki, Joshita Takashi, Matsuyama Nagahisa, Uchida Takashi, Ishikawa Akio, Ebihara Yoshiro
Department of Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Tokyo 160-8402, Japan.
Med Mol Morphol. 2006 Sep;39(3):164-8. doi: 10.1007/s00795-006-0323-x.
We report a tumor in an 80-year-old man that was difficult to distinguish from other tumors, i.e., small cell carcinoma of the lung, PNET/Ewing tumor, malignant lymphoma, or malignant melanoma (amelanotic), and which was finally identified as cutaneous neuroendocrine carcinoma using immunohistochemical and ultrastructural methods. Autopsy did not show any tumors in the lungs, excluding the possibility of small cell carcinoma of the lung. Immunohistochemistry tests gave negative results for LCA, UCHL-1, CD3, and CD20, thereby excluding malignant lymphoma, and the negative results for S-100 protein and HMB-45 ruled out malignant melanoma. The possibility of PNET/Ewing sarcoma was also excluded because of negativity for CD99. In addition, the ultramicrostructure showed intercellular junctional complexes and neuroendocrine granules, indicating that the tumor had characteristics of both epithelial and neuroendocrine tissues. We therefore diagnosed the primary carcinoma of the skin as cutaneous neuroendocrine carcinoma.
我们报告了一例80岁男性患者身上的肿瘤，该肿瘤难以与其他肿瘤区分，如肺小细胞癌、原始神经外胚层肿瘤/尤因肉瘤、恶性淋巴瘤或恶性黑色素瘤（无色素型），最终通过免疫组织化学和超微结构方法确诊为皮肤神经内分泌癌。尸检未发现肺部有任何肿瘤，排除了肺小细胞癌的可能性。免疫组织化学检测结果显示LCA、UCHL-1、CD3和CD20均为阴性，从而排除了恶性淋巴瘤，S-100蛋白和HMB-45阴性排除了恶性黑色素瘤。由于CD99呈阴性，也排除了原始神经外胚层肿瘤/尤因肉瘤的可能性。此外，超微结构显示细胞间连接复合体和神经内分泌颗粒，表明该肿瘤具有上皮组织和神经内分泌组织的特征。因此，我们将皮肤原发性癌诊断为皮肤神经内分泌癌。
