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不同碳氢化合物对各种不完全燃烧过程排放物致癌潜能的相对重要性。

Relative significance of different hydrocarbons for the carcinogenic potency of emissions from various incomplete combustion processes.

作者信息

Pott F, Heinrich U

机构信息

Medical Institute for Environmental Hygiene, Heinrich Heine University of Düsseldorf, FR Germany.

出版信息

IARC Sci Publ. 1990(104):288-97.

PMID:1699890
Abstract

Animal experiments have shown that the carcinogenic activity of organic extracts of exhaust condensates is caused predominantly by PAHs containing 4-6 rings. The carcinogenic potency not only of PAH-containing extracts but also of the whole exhausts has often been estimated from their benzo[a]pyrene (BP) content. However, this simplified yardstick should not be applied for comparison of the carcinogenic potency of different types of PAH-containing exhausts. Epidemiological and experimental studies indicate that, for the induction of a certain tumour incidence, inhaled cigarette smoke contains about 100 times less BP and inhaled diesel exhaust contains about 1000 times less BP than the exhausts from coke ovens or heated tar pitch which yield the same results. This means that diesel exhaust and cigarette smoke contain--apart from PAHs--highly potent carcinogenic substances and/or they induce tumorigenic reactions which are very effective.

摘要

动物实验表明,废气冷凝物有机提取物的致癌活性主要由含4 - 6个环的多环芳烃引起。含多环芳烃提取物以及整个废气的致癌潜力通常是根据其苯并[a]芘(BP)含量来估算的。然而,这种简化的标准不应应用于比较不同类型含多环芳烃废气的致癌潜力。流行病学和实验研究表明,为了诱发一定的肿瘤发生率,吸入的香烟烟雾中的BP含量比产生相同结果的焦炉废气或加热焦油沥青废气少约100倍,吸入的柴油废气中的BP含量则少约1000倍。这意味着柴油废气和香烟烟雾除了含有多环芳烃外,还含有高效致癌物质和/或它们能诱发非常有效的致瘤反应。

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