Katier N, Uiterwaal C S P M, de Jong B M, Verheij T J M, van der Ent C K
Departments of Pediatric Pulmonology, University Medical Center Utrecht, Utrecht, The Netherlands.
Pediatr Pulmonol. 2006 Nov;41(11):1058-64. doi: 10.1002/ppul.20492.
The single occlusion technique (SOT) is a simple and noninvasive technique for measurement of passive respiratory mechanics in infants. Reference values based on measurements of a large population of healthy infants performed outside specialized research laboratories are lacking. The aim of this study was to present reference values for passive respiratory mechanics based on a large population of healthy term neonates and infants measured during natural sleep in routine care. As part of the ongoing Wheezing Illnesses Study Leidsche Rijn (WHISTLER), the compliance (C(rs)) and resistance (R(rs)) of the respiratory system were measured in 450 healthy unsedated neonates and infants with a mean age of 4.6 +/- 1.3 weeks. Multivariable regression analysis, with gestational age, age at measurement, body size, sex, and ethnicity as possible predictors, was carried out to estimate prediction equations for mean C(rs) and R(rs) values. Technically acceptable lung function measurements could be performed in 328 (73%) neonates and infants. Median C(rs) was 39.5 (range 14.8-79.1) ml/kPa and median R(rs) was 7.4 (range 3.8-19.5) kPa/L/sec. The following regression equations for C(rs) and R(rs) were obtained: ln C(rs) = 1.677 + 1.3 x 10(-4) x birth weight (g) + 0.030 x birth length (cm) and ln R(rs) = 2.496-3.1 x 10(-6) x birth length(3) (cm(3)) - 0.114 x sex. We provided reference values for passive respiratory mechanics using the SOT in a large population of healthy term neonates and infants measured during natural sleep. These data provide a frame of reference for assessing the normality of SOT measurements performed in routine care.
单阻塞技术（SOT）是一种用于测量婴儿被动呼吸力学的简单且无创的技术。目前缺乏基于在专业研究实验室之外对大量健康婴儿进行测量得出的参考值。本研究的目的是给出基于大量健康足月儿和婴儿在常规护理自然睡眠期间测量得到的被动呼吸力学参考值。作为正在进行的莱顿莱茵河喘息疾病研究（WHISTLER）的一部分，对450名平均年龄为4.6±1.3周、未使用镇静剂的健康新生儿和婴儿测量了呼吸系统的顺应性（C(rs)）和阻力（R(rs)）。以胎龄、测量时的年龄、体型、性别和种族作为可能的预测因素进行多变量回归分析，以估计平均C(rs)和R(rs)值的预测方程。328名（73%）新生儿和婴儿能够进行技术上可接受的肺功能测量。C(rs)中位数为39.5（范围14.8 - 79.1）ml/kPa，R(rs)中位数为7.4（范围3.8 - 19.5）kPa/L/秒。得到了以下C(rs)和R(rs)的回归方程：ln C(rs) = 1.677 + 1.3×10⁻⁴×出生体重（g）+ 0.030×出生身长（cm），ln R(rs) = 2.496 - 3.1×10⁻⁶×出生身长³（cm³） - 0.114×性别。我们给出了在大量健康足月儿和婴儿自然睡眠期间使用SOT测量被动呼吸力学的参考值。这些数据为评估常规护理中SOT测量的正常性提供了一个参考框架。
