Huang Jianfeng, Zhang Hao, Zhang Mingzhi, Zhang Xiaobo, Wang Libo
1 Respiratory Department, Children's Hospital of FuDan University, Shanghai 201102, China ; 2 Respiratory Department, Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
J Thorac Dis. 2016 Mar;8(3):513-9. doi: 10.21037/jtd.2016.02.69.
Respiratory disease is a major cause of morbidity and mortality in infants and has a large impact on health care. The aim of this study was to present the reference values of resistance and compliance by using a single occlusion technique (SOT) in healthy infants in Southeast China.
Respiratory compliance (Crs) and respiratory resistance (Rrs) were measured in healthy infants, aged 1-96 weeks, by using SOT in the Children's Hospital of FuDan University (Shanghai, China). For comparison, the infants were grouped by age as follows: 1-24, 25-48, 49-72 and 73-96 weeks. Multiple regression analysis was performed using age, length, weight, and body mass index (BMI) as the independent variables to obtain predictive equations, separated according to sex.
We measured 205 healthy infants from birth up to 96 weeks of age (112 boys, 93 girls). Height and weight increased significantly with age. The Rrs declined with length, whereas the Crs increased. The median Rrs was 5.04 kPa/L/sec (range, 3.73-6.82 kPa/L/sec), and the mean Crs was 119.52±60.47 mL/kPa. Regression equations for Rrs and Crs were obtained.
We obtained reference values for passive respiratory mechanics by using SOT in healthy infants from Southeast China. These data provide references for assessing the normality of SOT measurements in infants.
呼吸系统疾病是婴儿发病和死亡的主要原因，对医疗保健有重大影响。本研究的目的是通过单阻断技术（SOT）呈现中国东南部健康婴儿的阻力和顺应性参考值。
在复旦大学附属儿科医院（中国上海），采用SOT对1至96周龄的健康婴儿进行呼吸顺应性（Crs）和呼吸阻力（Rrs）测量。为作比较，将婴儿按年龄分组如下：1至24周、25至48周、49至72周和73至96周。以年龄、身长、体重和体重指数（BMI）作为自变量进行多元回归分析，以获得按性别区分的预测方程。
我们测量了205名从出生至96周龄的健康婴儿（112名男婴，93名女婴）。身高和体重随年龄显著增加。Rrs随身长下降，而Crs上升。Rrs的中位数为5.04 kPa/L/秒（范围3.73至6.82 kPa/L/秒），Crs的平均值为119.52±60.47 mL/kPa。获得了Rrs和Crs的回归方程。
我们通过SOT获得了中国东南部健康婴儿被动呼吸力学的参考值。这些数据为评估婴儿SOT测量的正常性提供了参考。
