Mai Xiao-Mei, Almqvist Catarina, Nilsson Lennart, Wickman Magnus
Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada.
Arch Dis Child. 2007 Oct;92(10):881-6. doi: 10.1136/adc.2006.110692. Epub 2007 May 2.
We aimed to assess increased birth weight or birth length in relation to allergic diseases at 4 years of age, taking body mass index (BMI) at age 4 as a covariate in the adjustment.
The parents of a large prospective birth cohort answered questionnaires on environmental factors and allergic symptoms when their children were 2 months and 1, 2 and 4 years old. Perinatal data on weight and length at birth were received from the child care health centres. The children were clinically examined at 4 years of age and height and weight recorded. Blood was drawn for analysis of specific IgE antibodies to common inhalant allergens. Risk associations between birth anthropometric measures and wheeze, allergic diseases or sensitisation were estimated in multivariate logistic regression analyses (n = 2869).
There were no clear overall associations between birth weight and allergic diseases at 4 years of age. Birth length > or =90th percentile was inversely associated with any wheeze at age 4 (adjusted OR 0.64, 95% CI 0.44 to 0.92) but was significantly associated only with late-onset wheeze (adjusted OR 0.40, 95% CI 0.21 to 0.77). No such associations were seen for persistent or transient wheeze, eczema, rhinitis or allergic sensitisation. Transient wheeze during the first 2 years of age tended to be associated with increased BMI at age 4.
Increased birth weight was not associated with wheeze or allergic disease. Increased birth length may play a protective role in late-onset wheeze in early childhood.
我们旨在评估出生体重增加或出生身长增加与4岁时过敏性疾病之间的关系，并将4岁时的体重指数（BMI）作为协变量进行调整。
一个大型前瞻性出生队列的父母在其孩子2个月大、1岁、2岁和4岁时回答了关于环境因素和过敏症状的问卷。出生时体重和身长的围产期数据来自儿童保健健康中心。在4岁时对儿童进行临床检查并记录身高和体重。采集血液以分析针对常见吸入性过敏原的特异性IgE抗体。在多因素逻辑回归分析（n = 2869）中估计出生人体测量指标与喘息、过敏性疾病或致敏之间的风险关联。
4岁时出生体重与过敏性疾病之间没有明显的总体关联。出生身长≥第90百分位数与4岁时的任何喘息呈负相关（校正比值比0.64，95%可信区间0.44至0.92），但仅与迟发性喘息显著相关（校正比值比0.40，95%可信区间0.21至0.77）。持续性或短暂性喘息、湿疹、鼻炎或过敏致敏未发现此类关联。2岁前的短暂性喘息往往与4岁时BMI增加有关。
出生体重增加与喘息或过敏性疾病无关。出生身长增加可能对幼儿迟发性喘息起到保护作用。
