一名患有肌肉萎缩症的患者在接受短期利奈唑胺治疗后因视神经病变导致完全失明。
Complete blindness after optic neuropathy induced by short-term linezolid treatment in a patient suffering from muscle dystrophy.
作者信息
Azamfirei Leonard, Copotoiu Sanda-Maria, Branzaniuc Klara, Szederjesi Janos, Copotoiu Ruxandra, Berteanu Cristina
机构信息
Department of Intensive Care, University of Medicine and Pharmacy Targu-Mures, Romania.
出版信息
Pharmacoepidemiol Drug Saf. 2007 Apr;16(4):402-4. doi: 10.1002/pds.1320.
We present a case of severe optic neuropathy following linezolid treatment, which led to complete irreversible blindness, in a patient with progressive muscular dystrophy, treated with linezolid for 16 days for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Interruption of antibiotic therapy did not lead to remission of ocular symptoms. Administration of linezolid may lead to severe neuropathy even in the case of short-term treatment.
我们报告了一例在患有进行性肌营养不良的患者中，使用利奈唑胺治疗耐甲氧西林金黄色葡萄球菌（MRSA）肺炎16天后出现严重视神经病变并导致完全不可逆失明的病例。中断抗生素治疗并未使眼部症状缓解。即使是短期治疗，使用利奈唑胺也可能导致严重神经病变。
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