Vicus D, Korach J, Friedman E, Rizel S, Ben-Baruch G
Obstetrics and Gynecology Department, Sheba Tel--Hashomer Medical Center and Sackler School of Medicine, Tel-Aviv, Israel.
Gynecol Oncol. 2006 Dec;103(3):1144-6. doi: 10.1016/j.ygyno.2006.07.037. Epub 2006 Sep 26.
Vulvar cancer rarely sends metastases to distant sites.
A 49-year-old female presented with a vulvar mass. The histologic examination revealed an infiltrating lesion with free surgical margins and no evidence of lymph node involvement. Four months following surgery, due to a bloody breast discharge and a palpable breast lump an excisional biopsy was performed. The histological evaluation revealed morphological features suggestive of metastatic squamous cell carcinoma. The morphological, immunohistochemical and in situ hybridization findings were consistent with a breast metastatic nodule of squamous cell carcinoma arising from the primary vulvar cancer.
We conclude that the specimens are from the same origin therefore making the breast lesion a metastasis from the vulva.
外阴癌很少发生远处转移。
一名49岁女性出现外阴肿物。组织学检查显示为浸润性病变，手术切缘阴性，无淋巴结受累证据。术后4个月，因乳头血性溢液及可触及乳腺肿块行切除活检。组织学评估显示形态学特征提示为转移性鳞状细胞癌。形态学、免疫组化及原位杂交结果均符合源自原发性外阴癌的乳腺鳞状细胞癌转移结节。
我们得出结论，这些标本来自同一来源，因此乳腺病变是外阴转移所致。
