White-Scharf M E, Rosenberg L T
Infect Immun. 1978 Oct;22(1):18-21. doi: 10.1128/iai.22.1.18-21.1978.
The genetic polymorphism in early, immunoglobulin M, responsiveness to the Klebsiella pneumoniae type 47 polysaccharide (K47-PS) is determinant specific, and L-rhamnose is probably the determinant against which differential responsiveness is expressed. This is inferred from tests of the response to the cross-reacting Streptococcus pneumoniae type 23 and non-cross-reacting pneumococcal polysaccharides of known chemical construction. B10.2/Sn new-line mice are high responders and BALB/c mice are low responders to K47-PS. Upon immunization with killed S. pneumoniae type 23, these strains produce cross-reacting antibody to K47-PS. The cross-reacting antibody responses of these strains are congruent with their responses to K47-PS.
早期免疫球蛋白M对肺炎克雷伯菌47型多糖（K47-PS）反应的基因多态性具有决定簇特异性，L-鼠李糖可能是表达差异反应性所针对的决定簇。这是通过对已知化学结构的交叉反应性肺炎链球菌23型和非交叉反应性肺炎球菌多糖的反应测试推断出来的。B10.2/Sn新品系小鼠对K47-PS是高反应者，而BALB/c小鼠是低反应者。用灭活的肺炎链球菌23型免疫后，这些品系产生针对K47-PS的交叉反应抗体。这些品系的交叉反应抗体反应与其对K47-PS的反应一致。
