SME-3，粘质沙雷氏菌碳青霉烯水解β-内酰胺酶SME家族的一个新成员。
SME-3, a novel member of the Serratia marcescens SME family of carbapenem-hydrolyzing beta-lactamases.
作者信息
Queenan Anne Marie, Shang Wenchi, Schreckenberger Paul, Lolans Karen, Bush Karen, Quinn John
机构信息
Antimicrobial Agents Research Team, Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA.
出版信息
Antimicrob Agents Chemother. 2006 Oct;50(10):3485-7. doi: 10.1128/AAC.00363-06.
Abstract
Imipenem-resistant Serratia marcescens isolates were cultured from a lung transplant patient given multiple antibiotics over several months. The strains expressed SME-3, a beta-lactamase of the rare SME carbapenem-hydrolyzing family. SME-3 differed from SME-1 by a single amino acid substitution of tyrosine for histidine at position 105, but the two beta-lactamases displayed similar hydrolytic profiles.
摘要
从一名接受了数月多种抗生素治疗的肺移植患者身上培养出了耐亚胺培南的粘质沙雷氏菌分离株。这些菌株表达了SME-3，这是一种罕见的SME碳青霉烯水解酶家族的β-内酰胺酶。SME-3与SME-1的区别在于第105位氨基酸由组氨酸单氨基酸替换为酪氨酸，但这两种β-内酰胺酶显示出相似的水解谱。
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