Lin X, Hu Q, Zhang R, Hu Y, Xu X, Lv H
Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou, China.
Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
J Hosp Infect. 2016 Sep;94(1):65-7. doi: 10.1016/j.jhin.2016.04.006. Epub 2016 Apr 21.
Eighty-three carbapenem-resistant Serratia marcescens isolates were recovered from Zhejiang Provincial People's Hospital, China. The minimum inhibitory concentrations of imipenem, meropenem, and ertapenem for all isolates were 2 to >128 μg/mL. Polymerase chain reaction indicated that 63 S. marcescens isolates produced Klebsiella pneumoniae carbapenemase (KPC)-2. Clone A (15 isolates) and clone B (41 isolates) were the two dominant clones and clone A strains were gradually replaced by clone B strains between 2011 and 2014. The results indicate that blaKPC-2-positive S. marcescens emerged in our hospital as the major mechanism of carbapenem resistance.
从中国浙江省人民医院分离出83株耐碳青霉烯类的粘质沙雷氏菌。所有分离株对亚胺培南、美罗培南和厄他培南的最低抑菌浓度为2至>128μg/mL。聚合酶链反应表明，63株粘质沙雷氏菌分离株产生肺炎克雷伯菌碳青霉烯酶（KPC）-2。克隆A（15株）和克隆B（41株）是两个主要克隆，2011年至2014年间，克隆A菌株逐渐被克隆B菌株取代。结果表明，blaKPC-2阳性粘质沙雷氏菌在我院出现，成为碳青霉烯耐药的主要机制。
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