Pandya Chirag, Blazey Holli, Budev Marie M, Mehta Atul C, Minai Omar A
Huron Hospital/Cleveland Clinic Health System, Cleveland, Ohio, USA.
Prog Transplant. 2006 Sep;16(3):239-41. doi: 10.1177/152692480601600309.
Acanthosis nigricans was observed 3 months after single lung transplantation in a 51-year-old African American woman with idiopathic pulmonary fibrosis. The patient had no endocrinological abnormalities and was not taking any medications known to cause acanthosis nigricans; extensive investigation did not reveal an underlying malignant process. Because acanthosis nigricans may occur as a paraneoplastic phenomenon, it is important to rule out an underlying malignancy. This is especially important in solid-organ transplant recipients receiving chronic immunosuppressive therapy.
一名51岁患有特发性肺纤维化的非裔美国女性在单肺移植3个月后出现了黑棘皮症。该患者没有内分泌异常，也未服用任何已知可导致黑棘皮症的药物；广泛检查未发现潜在的恶性病变。由于黑棘皮症可能作为副肿瘤现象出现，因此排除潜在恶性肿瘤很重要。这在接受慢性免疫抑制治疗的实体器官移植受者中尤为重要。
