Quint Koen D, Edelbroek Jeroen R J, Gelderblom A J Hans, van Doorn Romco, Vermeer Maarten H
Leids Universitair Medisch Centrum, Leiden.
Ned Tijdschr Geneeskd. 2013;157(38):A6560.
Paraneoplastic dermatoses may be the first manifestation of a malignancy. Rapid recognition is therefore important.
A 72-year-old woman who had been treated in the past for metastasised neuroendocrine carcinoma and had undergone curative treatment for stage-1c endometrial carcinoma developed three paraneoplastic dermatoses over a 2-year period: acanthosis nigricans, tripe palms and acquired hypertrichosis lanuginosa. Half a year later, cutaneous metastases derived from the endometrial carcinoma treated 12 years prior were discovered.
The development of three paraneoplastic dermatoses in a short period of time is rare. Acanthosis nigricans, tripe palms and acquired hypertrichosis lanuginosa can develop in association with both neuroendocrine and endometrial carcinoma. The sudden development of paraneoplastic dermatoses is frequently a forewarning of progression of the malignancy.
副肿瘤性皮肤病可能是恶性肿瘤的首发表现。因此，快速识别很重要。
一名72岁女性，既往曾接受转移性神经内分泌癌治疗，且已接受1c期子宫内膜癌的根治性治疗，在2年时间内出现了三种副肿瘤性皮肤病：黑棘皮病、掌跖角化病和获得性胎毛增多症。半年后，发现了源自12年前治疗过的子宫内膜癌的皮肤转移瘤。
短时间内出现三种副肿瘤性皮肤病的情况较为罕见。黑棘皮病、掌跖角化病和获得性胎毛增多症可与神经内分泌癌和子宫内膜癌同时发生。副肿瘤性皮肤病的突然出现常常是恶性肿瘤进展的先兆。
