Kruesi M J, Rapoport J L, Hamburger S, Hibbs E, Potter W Z, Lenane M, Brown G L
National Institute of Mental Health, Child Psychiatry Branch, Bethesda, MD 20892.
Arch Gen Psychiatry. 1990 May;47(5):419-26. doi: 10.1001/archpsyc.1990.01810170019003.
Cerebrospinal fluid levels of 5-hydroxyindoleacetic acid, a metabolite of serotonin, were measured in relation to aggression, impulsivity, and social functioning in 29 children and adolescents with disruptive behavior disorders. The cerebrospinal fluid 5-hydroxyindoleacetic acid level was low compared with that of age-, sex-, and race-matched patients with obsessive-compulsive disorder. Within the disruptive group, significant negative correlations with age-corrected 5-hydroxyindoleacetic acid level were seen for the child's report of aggression toward people and the expressed emotionality of the child toward his or her mother; other correlations of age-corrected 5-hydroxyindoleacetic acid level with measures of aggression were in the expected negative direction but did not reach statistical significance. Impulsivity per se and socioenvironmental factors were not significantly related to cerebrospinal fluid 5-hydroxyindoleacetic acid concentration.
在29名患有破坏性行为障碍的儿童和青少年中，测量了血清素代谢产物5-羟吲哚乙酸的脑脊液水平，并将其与攻击性、冲动性和社会功能进行关联分析。与年龄、性别和种族匹配的强迫症患者相比，破坏性行为障碍组儿童脑脊液中5-羟吲哚乙酸水平较低。在破坏性行为障碍组内，儿童对他人攻击行为的自我报告以及儿童对其母亲表达的情绪与经年龄校正的5-羟吲哚乙酸水平呈显著负相关；经年龄校正的5-羟吲哚乙酸水平与其他攻击性测量指标的相关性虽呈预期的负向，但未达到统计学显著性。冲动性本身以及社会环境因素与脑脊液中5-羟吲哚乙酸浓度无显著相关性。
