Kruesi M J, Hibbs E D, Zahn T P, Keysor C S, Hamburger S D, Bartko J J, Rapoport J L
Child Psychiatry, National Institute of Mental Health, Bethesda, Md.
Arch Gen Psychiatry. 1992 Jun;49(6):429-35. doi: 10.1001/archpsyc.1992.01820060009001.
A 2-year prospective follow-up study of 100% (N = 29) of a sample of children and adolescents with disruptive behavior disorders found that the baseline lumbar cerebrospinal fluid monoamine metabolite concentration and autonomic nervous system activity predicted some subsequent outcomes. The 5-hydroxyindoleacetic acid concentration significantly predicted severity of physical aggression during follow-up. The skin conductance level significantly predicted institutionalization. Correlations were in predicted directions with lower cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and autonomic activity correlated with poor outcome. Moreover, in multivariate analyses, which included nonlaboratory measures as predictors, cerebrospinal fluid and autonomic measures still contributed significantly to the prediction. However, hypothesized predictions of cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations for suicide attempts and of low autonomic nervous system activity for arrests were not supported thus far. Patients are still at risk; consequently, these results must be considered preliminary. Nonetheless, the results suggest that further investigation of relationships between biological factors and outcome of children with disruptive behavior disorders is warranted.
一项针对患有破坏性行为障碍的儿童和青少年样本（100%，N = 29）的为期2年的前瞻性随访研究发现，基线腰椎脑脊液单胺代谢物浓度和自主神经系统活动可预测一些后续结果。5-羟吲哚乙酸浓度显著预测随访期间身体攻击行为的严重程度。皮肤电导水平显著预测住院情况。脑脊液5-羟吲哚乙酸浓度降低以及自主神经活动与不良结果相关，相关性符合预测方向。此外，在包括非实验室测量作为预测指标的多变量分析中，脑脊液和自主神经测量指标仍对预测有显著贡献。然而，目前关于脑脊液5-羟吲哚乙酸浓度对自杀未遂的假设预测以及低自主神经系统活动对被捕的假设预测尚未得到证实。患者仍处于风险之中；因此，这些结果必须被视为初步的。尽管如此，结果表明有必要进一步研究破坏性行为障碍儿童的生物学因素与结果之间的关系。
