Sena Ligia Moreiras, Zucolotto Silvana Maria, Reginatto Flávio Henrique, Schenkel Eloir Paulo, De Lima Thereza Christina Monteiro
Laboratory of Neuropharmacology, Department of Pharmacology - Center of Biological Sciences, Federal University of Santa Catarina, Campus Universitário, Trindade, Florianópolis, SC, 88049-900, Brazil.
Exp Biol Med (Maywood). 2009 Aug;234(8):967-75. doi: 10.3181/0902-RM-84. Epub 2009 Jun 2.
Passiflora edulis has been used in traditional medicine as a sedative and to treat or prevent central disorders such as anxiety and insomnia. In this study, the central effects of the aqueous extract (AE), the butanolic fraction (BF), and the aqueous residual fraction (ARF) obtained from the pericarp of P. edulis flavicarpa were investigated in mice and the possible compounds involved in these putative neuropharmacologic effects were determined. AE, BF, and ARF increased the total time spent in the light compartment of the light:dark box, an anxiolytic-like effect, and AE also potentiated the hypnotic effects of ethyl ether, a sedative effect. The thin layer chromatography and high-performance liquid chromatography analysis indicated the predominance of C-glycosylflavonoids in these extracts and fractions, which were identified as isoorientin, vicenin-2, spinosin, and 6,8-di-C-glycosylchrysin.
西番莲在传统医学中一直被用作镇静剂，用于治疗或预防诸如焦虑和失眠等中枢神经系统疾病。在本研究中，对从黄果西番莲果皮中获得的水提取物（AE）、丁醇馏分（BF）和水残余馏分（ARF）对小鼠的中枢作用进行了研究，并确定了这些假定的神经药理作用中可能涉及的化合物。AE、BF和ARF增加了在明暗箱实验中在亮区所花费的总时间，呈现出抗焦虑样作用，并且AE还增强了乙醚的催眠作用，即镇静作用。薄层色谱和高效液相色谱分析表明这些提取物和馏分中主要为C-糖基黄酮类化合物，它们被鉴定为异荭草素、异荭草苷-2、斯皮诺素和6,8-二-C-糖基白杨素。
