Maylor Elizabeth A, Simpson Ellen E A, Secker David L, Meunier Nathalie, Andriollo-Sanchez Maud, Polito Angela, Stewart-Knox Barbara, McConville Chris, O'Connor Jacqueline M, Coudray Charles
Department of Psychology, University of Warwick, Coventry CV4 7AL, UK.
Br J Nutr. 2006 Oct;96(4):752-60.
A randomised double-blind placebo-controlled design was employed to investigate the effects of Zn supplementation on cognitive function in 387 healthy adults aged 55-87 years. Several measures of visual memory, working memory, attention and reaction time were obtained using the Cambridge Automated Neuropsychological Test Battery at baseline and then after 3 and 6 months of 0 (placebo), 15 or 30 mg Zn/d. Younger adults (< 70 years) performed significantly better on all tests than older adults (> 70 years), and performance improved with practice on some measures. For two out of eight dependent variables, there were significant interactions indicating a beneficial effect (at 3 months only) of both 15 and 30 mg/d on one measure of spatial working memory and a detrimental effect of 15 mg/d on one measure of attention. Further work is required to establish whether these findings generalise to older adults in poorer mental and physical health and with less adequate Zn intake and status than the present sample.
采用随机双盲安慰剂对照设计，研究补充锌对387名年龄在55至87岁的健康成年人认知功能的影响。在基线时，然后在服用0（安慰剂）、15或30毫克锌/天3个月和6个月后，使用剑桥自动神经心理测试组合获得了视觉记忆、工作记忆、注意力和反应时间的多项测量结果。较年轻的成年人（<70岁）在所有测试中的表现均显著优于较年长的成年人（>70岁），并且在某些测量指标上，表现会随着练习而提高。在八个因变量中的两个变量上，存在显著的交互作用，表明15毫克/天和30毫克/天对一项空间工作记忆测量指标均有有益影响（仅在3个月时），而15毫克/天对一项注意力测量指标有不利影响。需要进一步开展研究，以确定这些发现是否适用于身心健康状况较差、锌摄入量和锌状态不如当前样本的老年人。
