Deretic Dusanka
Department of Surgery, Division of Ophthalmology, University of New Mexico, Albuquerque, NM 87131, USA.
Vision Res. 2006 Dec;46(27):4427-33. doi: 10.1016/j.visres.2006.07.028. Epub 2006 Sep 28.
This review summarizes the most recent progress in the understanding of the role of rhodopsin C-terminal domain in the regulation of intracellular trafficking and photoreceptor morphogenesis. A proposed cascade of molecular interactions, initiated by the rhodopsin C-terminal sequence VXPX-COOH during trafficking from the Golgi/TGN in retinal photoreceptors, is relayed by the small GTPase ARF4 to the downstream effectors. One of the candidates for an ARF4 effector is the ARF-GAP ASAP1, which may function as a subunit of, or form a novel protein coat involved in trafficking from the TGN and in cytoskeletal remodeling, whose assembly is regulated by the binding of ARF4 to rhodopsin, and whose function is essential for the polarized trafficking toward the ROS.
本综述总结了在理解视紫红质C末端结构域在细胞内运输调控和光感受器形态发生中的作用方面的最新进展。在视网膜光感受器中从高尔基体/反式高尔基体网络运输过程中，由视紫红质C末端序列VXPX-COOH引发的一系列分子相互作用，通过小GTP酶ARF4传递给下游效应器。ARF4效应器的候选者之一是ARF-GAP ASAP1，它可能作为一个亚基起作用，或形成一种参与从反式高尔基体网络运输和细胞骨架重塑的新型蛋白质衣被，其组装受ARF4与视紫红质结合的调控，其功能对于向视网膜外节的极性运输至关重要。
