Messina Antonietta, De Fusco Carolina, Monda Vincenzo, Esposito Maria, Moscatelli Fiorenzo, Valenzano Anna, Carotenuto Marco, Viggiano Emanuela, Chieffi Sergio, De Luca Vincenzo, Cibelli Giuseppe, Monda Marcellino, Messina Giovanni
Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples Naples, Italy.
Neapolitan Brain Group (NBG), Clinic of Child and Adolescent Neuropsychiatry, Department of Mental, Physical Health and Preventive Medicine, Second University of Naples Naples, Italy.
Front Neural Circuits. 2016 Aug 25;10:66. doi: 10.3389/fncir.2016.00066. eCollection 2016.
Hypocretin/orexin (ORX) are two hypothalamic neuropeptides discovered in 1998. Since their discovery, they have been one of the most studied neuropeptide systems because of their projecting fields innervating various brain areas. The orexinergic system is tied to sleep-wakefulness cycle, and narcolepsy is a consequence of their system hypofunction. Orexinergic system is also involved in many other autonomic functions such as feeding, thermoregulation, cardiovascular and neuroendocrine regulation. The main aim of this mini review article is to investigate the relationship between ORX and thyroid system regulation. Although knowledge about the ORX system is evolving, its putative effects on hypothalamic-pituitary-thyroid (HPT) axis still appear unclear. We analyzed some studies about ORX control of HPT axis to know better the relationship between them. The studies that were analyzed suggest Hypocretin/ORX to modulate the thyroid regulation, but the nature (excitatory or inhibitory) of this possible interaction remains actually unclear and needs to be confirmed.
下丘脑分泌素/食欲素（ORX）是1998年发现的两种下丘脑神经肽。自发现以来，由于其投射区域支配着各个脑区，它们一直是研究最多的神经肽系统之一。食欲素能系统与睡眠-觉醒周期相关，发作性睡病是该系统功能减退的结果。食欲素能系统还参与许多其他自主功能，如进食、体温调节、心血管和神经内分泌调节。这篇小型综述文章的主要目的是研究ORX与甲状腺系统调节之间的关系。尽管关于ORX系统的知识不断发展，但其对下丘脑-垂体-甲状腺（HPT）轴的假定作用仍不明确。我们分析了一些关于ORX对HPT轴控制的研究，以便更好地了解它们之间的关系。所分析的研究表明下丘脑分泌素/ORX可调节甲状腺调节，但这种可能相互作用的性质（兴奋性或抑制性）目前仍不明确，需要进一步证实。
