Umetsu Dale T, Dekruyff Rosemarie H
Division of Immunology, Children's Hospital Boston, Harvard Medical School, Karp Laboratories, Rm 10127, One Blackfan Circle, Boston, MA 02115, USA.
Curr Opin Immunol. 2006 Dec;18(6):727-32. doi: 10.1016/j.coi.2006.09.007. Epub 2006 Sep 28.
Allergic diseases and asthma are caused by dysregulated Th2-biased immune responses to environmental allergens in genetically predisposed individuals. Over the past several years there has been much progress in understanding the mechanisms by which Th2 responses are generated and the pathogenic role of natural killer T cells in asthma. In addition, there has been much progress in understanding the mechanisms of tolerance to allergens, the role of natural and adaptive allergen-specific regulatory T cells, and the strategies to prevent or to reverse allergic disease and asthma. Impaired expansion of regulatory T cells is hypothesized to lead to the development of allergy and asthma, and treatment to induce allergen-specific regulatory T cells could provide curative therapies for these problems.
过敏性疾病和哮喘是由遗传易感性个体对环境过敏原的Th2偏向性免疫反应失调引起的。在过去几年中，在理解Th2反应产生的机制以及自然杀伤T细胞在哮喘中的致病作用方面取得了很大进展。此外，在理解过敏原耐受机制、天然和适应性过敏原特异性调节性T细胞的作用以及预防或逆转过敏性疾病和哮喘的策略方面也取得了很大进展。调节性T细胞的扩增受损被认为会导致过敏和哮喘的发生，诱导过敏原特异性调节性T细胞的治疗可能为这些问题提供治愈性疗法。
