Howard Jane K, Flier Jeffrey S
Endocrine Unit, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK.
Trends Endocrinol Metab. 2006 Nov;17(9):365-71. doi: 10.1016/j.tem.2006.09.007. Epub 2006 Sep 28.
Leptin and insulin are key hormones involved in the regulation of energy balance and glucose homeostasis. Development of resistance to the action of these hormones, which can occur with age, obesity and inflammation, appears to have a prime role in the pathogenesis of obesity and type 2 diabetes. Specific members of the suppressor of cytokine signaling (SOCS) family of proteins are now thought to have a role in the development of leptin and insulin resistance owing to their ability to inhibit leptin and insulin signaling pathways. In the case of leptin, current evidence suggests that SOCS3 appears to be of particular importance in the development of leptin resistance, whereas the ability to diminish insulin action has been described for several SOCS proteins (SOCS1, SOCS3, SOCS6 and SOCS7).
瘦素和胰岛素是参与能量平衡调节及葡萄糖稳态维持的关键激素。随着年龄增长、肥胖及炎症反应，机体可能会对这些激素产生抵抗，而这种抵抗的形成在肥胖症和2型糖尿病的发病机制中似乎起着主要作用。细胞因子信号转导抑制因子（SOCS）蛋白家族的特定成员，因其能够抑制瘦素和胰岛素信号通路，目前被认为在瘦素和胰岛素抵抗的发生发展中发挥作用。就瘦素而言，目前的证据表明，SOCS3在瘦素抵抗的发生中似乎尤为重要，而几种SOCS蛋白（SOCS1、SOCS3、SOCS6和SOCS7）均具有降低胰岛素作用的能力。
