Clarke Simon R, Foster Simon J
Department of Molecular Biology & Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.
Adv Microb Physiol. 2006;51:187-224. doi: 10.1016/S0065-2911(06)51004-5.
An important facet in the interaction between Staphylococcus aureus and its host is the ability of the bacterium to adhere to human extracellular matrix components and serum proteins. In order to colonise the host and disseminate, it uses a wide range of strategies, the molecular and genetic basis of which are multifactorial, with extensive functional overlap between adhesins. Here, we describe the current knowledge of the molecular features of the adhesive components of S. aureus, mechanisms of adhesion and the impact that these have on host-pathogen interaction.
金黄色葡萄球菌与其宿主之间相互作用的一个重要方面是该细菌粘附于人类细胞外基质成分和血清蛋白的能力。为了在宿主体内定殖和传播，它采用了多种策略，其分子和遗传基础是多因素的，粘附素之间存在广泛的功能重叠。在此，我们描述了目前关于金黄色葡萄球菌粘附成分的分子特征、粘附机制以及这些对宿主-病原体相互作用的影响的知识。
