一种多离子渗透的简单模型。简单孔隙模型中的单空位传导。
A simple model for multi-ion permeation. Single-vacancy conduction in a simple pore model.
作者信息
Schumaker M F, MacKinnon R
机构信息
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02254.
出版信息
Biophys J. 1990 Oct;58(4):975-84. doi: 10.1016/S0006-3495(90)82442-5.
Abstract
Recent experimental evidence suggests that certain membrane channels operate in a nearly ion-saturated state. We therefore consider a "single-vacancy" model of ion permeation: if a channel has n conducting sites, it will contain either n or n-1 ions. Simple analytical expressions for the current, conductance, and reversal potential under bi-ionic conditions are derived. The results are compared with those of single ion models and recent experiments on Ca2(+)-activated K+ channels.
摘要
最近的实验证据表明，某些膜通道在几乎离子饱和的状态下运作。因此，我们考虑离子渗透的“单空位”模型：如果一个通道有n个传导位点，它将包含n个或n - 1个离子。推导了双离子条件下电流、电导和反转电位的简单解析表达式。将结果与单离子模型的结果以及最近关于Ca2(+)激活的K+通道的实验结果进行了比较。
相似文献
1
A simple model for multi-ion permeation. Single-vacancy conduction in a simple pore model.一种多离子渗透的简单模型。简单孔隙模型中的单空位传导。
Biophys J. 1990 Oct;58(4):975-84. doi: 10.1016/S0006-3495(90)82442-5.
2
Modeling ion permeation through batrachotoxin-modified Na+ channels from rat skeletal muscle with a multi-ion pore.利用多离子通道对大鼠骨骼肌中经蟾毒素修饰的钠离子通道的离子渗透进行建模。
Biophys J. 1992 Feb;61(2):494-508. doi: 10.1016/S0006-3495(92)81854-4.
3
Energy barrier presented to ions by the vestibule of the biological membrane channel.生物膜通道前庭对离子呈现的能垒。
Biophys J. 1996 Apr;70(4):1628-42. doi: 10.1016/S0006-3495(96)79726-6.
4
Gated, ion-selective channels observed with patch pipettes in the absence of membranes: novel properties of a gigaseal.在无细胞膜情况下用膜片吸管观察到的门控离子选择性通道：千兆封接的新特性
Biophys J. 1993 Sep;65(3):1101-7. doi: 10.1016/S0006-3495(93)81149-4.
5
Dynamic ion-ion and water-ion interactions in ion channels.离子通道中的动态离子-离子和水-离子相互作用。
Biophys J. 1992 May;61(5):1316-31. doi: 10.1016/S0006-3495(92)81940-9.
6
Framework model for single proton conduction through gramicidin.通过短杆菌肽的单质子传导框架模型。
Biophys J. 2001 Jan;80(1):12-30. doi: 10.1016/S0006-3495(01)75992-9.
7
Brownian dynamics study of a multiply-occupied cation channel: application to understanding permeation in potassium channels.多占据阳离子通道的布朗动力学研究：应用于理解钾通道中的渗透作用
Biophys J. 1994 Apr;66(4):1028-38. doi: 10.1016/S0006-3495(94)80884-7.
8
Ion flow in the bath and flux interactions between channels.浴槽中的离子流动以及通道之间的通量相互作用。
Biophys J. 1994 Apr;66(4):989-95. doi: 10.1016/S0006-3495(94)80880-X.
9
Shaking stack model of ion conduction through the Ca(2+)-activated K+ channel.通过钙激活钾通道的离子传导的摆动堆叠模型。
Biophys J. 1992 Oct;63(4):1032-44. doi: 10.1016/S0006-3495(92)81668-5.
10
Multichannel recordings from membranes which contain gap junctions. II. Substates and conductance shifts.来自含有间隙连接的细胞膜的多通道记录。II. 亚状态和电导变化。
Biophys J. 1993 Oct;65(4):1387-95. doi: 10.1016/S0006-3495(93)81193-7.
引用本文的文献
1
Direct visualization of electric-field-stimulated ion conduction in a potassium channel.钾通道中电场刺激离子传导的直接可视化
Cell. 2025 Jan 9;188(1):77-88.e15. doi: 10.1016/j.cell.2024.12.006.
2
Building predictive Markov models of ion channel permeation from molecular dynamics simulations.从分子动力学模拟中构建离子通道渗透的预测性马尔可夫模型。
Biophys J. 2024 Nov 5;123(21):3832-3843. doi: 10.1016/j.bpj.2024.09.030. Epub 2024 Sep 28.
3
Multiscale Responsive Kinetic Modeling: Quantifying Biomolecular Reaction Flux under Varying Electrochemical Conditions.多尺度响应动力学建模：量化不同电化学条件下的生物分子反应通量。
bioRxiv. 2024 Aug 2:2024.08.01.606205. doi: 10.1101/2024.08.01.606205.
4
Ion Conduction Mechanisms in Potassium Channels Revealed by Permeation Cycles.离子通道中渗透循环揭示的钾离子传导机制。
J Chem Theory Comput. 2023 May 9;19(9):2574-2589. doi: 10.1021/acs.jctc.3c00061. Epub 2023 Apr 11.
5
Thermodynamics of ion binding and occupancy in potassium channels.钾通道中离子结合与占据的热力学
Chem Sci. 2021 Jun 2;12(25):8920-8930. doi: 10.1039/d1sc01887f. eCollection 2021 Jul 1.
6
Mechanism of activation at the selectivity filter of the KcsA K channel.KcsA K 通道选择性过滤器的激活机制。
Elife. 2017 Oct 10;6:e25844. doi: 10.7554/eLife.25844.
7
Effect of lithium on the electrical properties of polycystin-2 (TRPP2).锂对多囊蛋白-2（TRPP2）的电特性的影响。
Eur Biophys J. 2011 Sep;40(9):1029-42. doi: 10.1007/s00249-011-0715-2. Epub 2011 Jun 16.
8
Determining k channel activation curves from k channel currents often requires the goldman-hodgkin-katz equation.从 k 通道电流中确定 k 通道激活曲线通常需要 Goldman-Hodgkin-Katz 方程。
Front Cell Neurosci. 2009 Dec 23;3:20. doi: 10.3389/neuro.03.020.2009. eCollection 2009.
9
Ionic flow enhances low-affinity binding: a revised mechanistic view into Mg2+ block of NMDA receptors.离子流增强低亲和力结合：一种对 NMDA 受体镁离子阻断的修正作用机制。
J Physiol. 2010 Feb 15;588(Pt 4):633-50. doi: 10.1113/jphysiol.2009.178913. Epub 2009 Dec 21.
10
Sodium flux ratio in Na/K pump-channels opened by palytoxin.由岩沙海葵毒素打开的钠钾泵通道中的钠通量比率。
J Gen Physiol. 2007 Jul;130(1):41-54. doi: 10.1085/jgp.200709770. Epub 2007 Jun 11.
本文引用的文献
1
POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES.膜的电位、阻抗和整流。
J Gen Physiol. 1943 Sep 20;27(1):37-60. doi: 10.1085/jgp.27.1.37.
2
The effect of sodium ions on the electrical activity of giant axon of the squid.钠离子对鱿鱼巨大轴突电活动的影响。
J Physiol. 1949 Mar 1;108(1):37-77. doi: 10.1113/jphysiol.1949.sp004310.
3
The potassium permeability of a giant nerve fibre.巨神经纤维的钾通透性。
J Physiol. 1955 Apr 28;128(1):61-88. doi: 10.1113/jphysiol.1955.sp005291.
4
The function of calcium in the potassium permeability of human erythrocytes.钙在人红细胞钾通透性中的作用。
Biochim Biophys Acta. 1958 Dec;30(3):653-4. doi: 10.1016/0006-3002(58)90124-0.
5
Potassium flux ratio in voltage-clamped squid giant axons.电压钳制枪乌贼巨轴突中的钾离子通量比率。
J Gen Physiol. 1980 Jul;76(1):83-98. doi: 10.1085/jgp.76.1.83.
6
Unidirectional flux ratio for potassium ions in depolarized frog skeletal muscle.去极化蛙骨骼肌中钾离子的单向通量比
Am J Physiol. 1981 Jul;241(1):C68-75. doi: 10.1152/ajpcell.1981.241.1.C68.
7
Mechanism of ion permeation through calcium channels.离子通过钙通道的渗透机制。
Nature. 1984;309(5967):453-6. doi: 10.1038/309453a0.
8
The gramicidin A channel: a review of its permeability characteristics with special reference to the single-file aspect of transport.短杆菌肽A通道：对其通透性特征的综述，特别提及转运的单排方面。
J Membr Biol. 1981 Apr 30;59(3):155-71. doi: 10.1007/BF01875422.
9
Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cells.牛嗜铬细胞钙激活钾通道中的离子通透与阻断
J Gen Physiol. 1984 Aug;84(2):157-86. doi: 10.1085/jgp.84.2.157.
10
Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore.蛙肌钙通道的非选择性电导：单排孔道中的钙选择性
J Physiol. 1984 Aug;353:585-608. doi: 10.1113/jphysiol.1984.sp015352.
Zotero 插件