Masters Colin L, Beyreuther Konrad
Department of Pathology, The University of Melbourne, 3010, Victoria, Australia.
Brain. 2006 Nov;129(Pt 11):2823-39. doi: 10.1093/brain/awl251. Epub 2006 Sep 29.
It is now 100 years since the nosological definition of Alzheimer's disease emerged. In the first 80 years, very little progress was made in understanding the mechanisms that caused the brain to degenerate in a remarkably specific fashion (amyloid accumulation with neurofibrillary changes). Over the past 20 years, there has been an explosion of knowledge which continues today at an exponential rate. The molecular pathways underlying the synaptic dysfunction in Alzheimer's disease have delivered many validated therapeutic and diagnostic targets. A variety of therapeutic strategies aimed at disease modification are now in clinical development.
自阿尔茨海默病的疾病分类定义出现至今已有100年。在最初的80年里，对于导致大脑以一种非常特殊的方式退化（淀粉样蛋白积累伴神经原纤维变化）的机制，人们了解甚少。在过去20年里，知识呈爆炸式增长，且至今仍以指数级速度持续增长。阿尔茨海默病中突触功能障碍背后的分子途径已经产生了许多经过验证的治疗和诊断靶点。目前，多种旨在改变疾病进程的治疗策略正在进行临床开发。
